Hemangiosarcoma of the Bone in Dogs
Hemangiosarcoma is a fast spreading tumor of the endothelial cells -- a group of cells that form to line the inner surface of blood vessels, including veins, arteries, intestines, and the bronchi of lungs. Hemangiosarcomas affect the bones and may compromise the integrity of the bone involved, resulting in loss of strength leading to bone fractures. Such fractures may be seen without any prior trauma and are characteristic of cancers that affect the bones. This tumor commonly affects the bones of the limbs but may also affect other bones in the body, like the rib bones.
As with many types of cancers, hemangiosarcoma is usually diagnosed in older dogs.
Symptoms and Types
- If tumor is on leg, lameness and/or swelling
- Fracture due to weakness in bone
- Swelling at affected site
- Difficult breathing may be present if tumor involves the rib
- Pale mucous membranes (i.e., nostrils, lips, ears, genitals)
- Anemia due to blood loss from ruptured tumor
The exact cause for hemangiosarcoma of the bone is still unknown.
Your veterinarian will perform a thorough physical exam on your dog, including a complete blood profile, a chemical blood profile, a complete blood count, and a urinalysis. These tests may indicate whether any of the organs are being affected, and whether any other conditions are present. Some of the conditions that may be concurrent with hemangiosarcoma are regenerative anemia, which is determined by an abnormally high number of immature red blood cells; an abnormally low level of protein in the blood (hypoproteinemia); an abnormally high white blood cell count (leukocytosis), which can be indicative that the body is fighting off a diseased condition; a low level of platelets in the blood (thrombocytopenia), which are responsible for blood clotting; and blood cells of unequal or abnormal size (anisocytosis and poikilocytosis, respectively).
Radiographic studies of the affected bone will also reveal valuable information to help your veterinarian in the diagnosis of this tumor. Computed tomography (CT) scans can help to determine the extent of bone involvement and also help your veterinarian in planning an effective surgery. Biopsy may be attempted for a definitive diagnosis, but this may not be practical for this type of tumor, since it originates in the vessels.
A confirmative diagnosis may be based on finding spaces within the vessels that are filled with red blood cells, clots, dead cellular debris, and variable tumor cells.
Aggressive surgery remains the method of choice in the treatment of this tumor. The tumor, and possibly the surrounding area, will need to be removed entirely. If the tumor is occurring on a limb, the affected limb will most probably be amputated, a surgery which most dogs recover from well. An axial tumor -- one that is affecting the area of the head or trunk -- may be more difficult to treat. Chemotherapy along with surgery is the recommended treatment plan.
Living and Management
Your veterinarian will set up a schedule for progress evaluation visits, starting from the first month after initial treatment and every three months following. Chemotherapy medications have the possibility of toxic side effects, so your veterinarian will need to closely monitor your dog's stability, changing dosage as necessary. Routine X-rays will be taken of the chest, heart and abdomen to check for recurrence and progress.
After surgery, you should expect your dog to feel sore. Your veterinarian will give you pain medication for your dog to help minimize discomfort. Use pain medications with caution; one of the most preventable accidents with pets is overdose of medication. Follow all directions carefully.
You will need to limit your dog's activity while it heals, setting aside a quiet place for it to rest, away from household activity, children, and other pets. You might consider cage rest for your dog, to limit its physical activity. Trips outdoors for bladder and bowel relief should be kept short and easy for your dog to handle during the recovery period. Your veterinarian will tell you when it is safe for your dog to move about again. Most dogs recover well from amputation, and learn to compensate for the lost limb.
It is important to monitor your dog's food and water intake while it is recovering. If your dog does not feel up to eating, you may need to use a feeding tube so that it is getting all of the nutrition it needs to completely recover. Your veterinarian will show you how to use the feeding tube correctly, and will assist you in setting up a feeding schedule.
Each dog is different, and some will survive longer than others, but the average time of survival after surgery is six months. Less than ten percent will survive for one year after surgery.
An increase in the number of white blood cells (abnormal)
A condition of the cells; means that they are abnormally shaped
An in-depth examination of the properties of urine; used to determine the presence or absence of illness
Any type of pain or tenderness or lack of soundness in the feet or legs of animals
A tumor made up vascular tissue
A condition of the blood in which normal red blood cell counts or hemoglobin are lacking.
A condition in which cells are unequal.
The process of removing all or part of a body part; usually refers to a limb (arm or leg) and is done for medical reasons.