Acute Lymphoblastic Leukemia in Cats

 

Acute lymphoblastic leukemia is a disease in which cancerous lymphoblasts (cells that are in the beginning stage of development) and prolymphocytes (cells in the intermediate stage of development) reproduce, and then circulate through the bloodstream, entering into the body's organs. These cells will also infiltrate both the inside of the bone marrow and the outside (extramedullary) of the bone marrow, displacing hematopoietic stem cells.

 

Hematopoietic cells are the normal, healthy precursors of red blood cells, lymphocytes, erythrocytes, platelets, eosinophils, neutrophils, macrophages and mast cells. Cats with this disease will acquire impaired immunity, and will be inclined to contracting infections.

 

Symptoms and Types

 

• Generalized illness, no specific symptoms
• Tiny, non-raised purple spots on the skin, from hemorrhages beneath the skin (petechia), or dark red-purple spots on the gums, from ruptured blood vessels under the skin (ecchymotic)
• Inconstant symptoms, dependent upon which organs have been infiltrated by neoplastic (abnormal) cells

 

Causes

 

• Known cause in cats:
  • Feline leukemia virus infection (FeLV)

 

Diagnosis

 

You will need to give your veterinarian a thorough history of your cat's health and onset of symptoms. Your veterinarian will perform a thorough physical exam on your cat, taking into account the background medical history, and possible incidents that might have precipitated this condition. A complete blood profile will be conducted, including a chemical blood profile, a complete blood count, and a urinalysis. If cancer is suspected, your doctor will also need to take bone marrow biopsies (samples) for a microscopic (cytologic) examination of the cells. If malignant cancer cells are present, the examination will show lymphoblastic infiltration of the bone marrow. Abdominal x-rays may also be taken to check for an enlarged liver and/or an enlarged spleen.

 

 

Treatment

 

Animals can normally be treated on an outpatient basis. However, if your cat has low levels of red blood cells, platelets (the cells responsible for clotting), or other blood clotting factors, your cat should be hospitalized and given blood transfusions to prevent excessive bleeding. If your cat has been diagnosed with leukemia, your veterinarian will also prescribe a chemotherapeutic medicine to halt the growth of malignant cells. You will need to wear gloves when you give this medication to your cat.

 

Living and Management

 

If your cat is diagnosed with leukemia, you will need to keep it isolated from other animals. Your cat’s system will lack an immune response (immunocompromised) as a result of both the cancer and the therapy. In the process of destroying fast growing cancerous cells, chemotherapy will also destroy white blood cells responsible for fighting invasion, making your cat prone to infection. Even a simple cold can quickly become a fatal case of pneumonia. Red blood cells can also be affected; one possible side affect of a low red blood cell count is anemia. And blood platelets, the cells responsible for coagulation (clotting), can be affected as well. A low platelet count can result in bruising and excessive bleeding. Animals suffering from this disorder are prone to hemorrhage from lack of platelets. Your veterinarian will schedule follow-up appointments to monitor your cat’s peripheral blood count and bone marrow status. Unfortunately, the prognosis for acute lymphoblastic leukemia is grave.