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Polysuflated Glycosaminoglycan

Drug Details

  • Drug Name: Polysuflated Glycosaminoglycan
  • Common Name: Adequan
  • Generics: No generics available
  • Drug Type: PSGAG (Cartilage Protective Agent)
  • Used For: Degenerative Joint Disease (a form of joint inflammation or arthritis)
  • Species: Dogs
  • Administered: Injectable
  • How Dispensed: Prescription Only
  • Available Forms: 100mg/mL & 250mg/mL concentrations
  • FDA Approved: Yes



Polysuflated Glycosaminoglycan, injectable is an osteoarthritis medication that is used to treat traumatic and non-infectious abnormalities and arthritis associated with joint stiffness and limping.


Dosage and Administration


Polysuflated Glycosaminoglycan, injectable should be given according to your veterinarian’s instructions. 


The medication is given by IM (intramuscular injection). Your veterinarian may also inject the PSGAG directly into the joint (intra-articular).


Missed Dose?


If a dose of Polysuflated Glycosaminoglycan is missed, give it as soon as you remember.  If you remember when it is almost time for the next dose, skip the one you missed and get back on your regular schedule. Do NOT double the dosing.


Possible Side Effects


Side effects associated with intramuscular injection are few; injections directly to the joints may cause: 

  • Joint Pain
  • Swelling
  • Lameness


Other side effects include decreased ability for blood to clot. Signs of this include:

  • Bleeding from the nose
  • Blood in the stool
  • Dark and tarry stools


If you think your animal has any medical problems or side effects while taking Polysuflated Glycosaminoglycan (Adequan) please consult your veterinarian. 




Do not mix this medication with any other drugs or chemicals. Do not use in animals that are hypersensitive to this medication or are suspected to have a bleeding disorder.


This medication's manufacturer does not recommend using it on breeding, pregnant, or lactating animals.




Polysuflated Glycosaminoglycan should be stored at room temperatures between 64-77oF.


Drug Interactions


Consult your veterinarian when giving other medications, including non-steroidal anti-inflammatory drugs (NSAIDs), such as Carprofen, deracoxib, etodolac, aspirin, meloxicam, or any drugs that may affect blood clotting such as heparin or warfarin. You should also consult your veterinarian if your animal is taking any supplements or vitamins.


Signs of Toxicity/Overdose


Overdose of Polysuflated Glycosaminoglycan (Adequan) is rare but could cause: 

  • Joint Pain
  • Swelling
  • Lameness


If you suspect or know your animal has had an overdose, please contact your veterinarian or emergency vet clinic immediately.

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