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Mitotane is used in the treatment of Cushing’s disease (hyperadrenocorticism) and related symptoms in dogs.
Always follow the dosage instructions from your veterinarian and any special instructions (e.g., give with food or give in the morning).
Please wear gloves when handling this medication. Wash hands well after handling.
When Mitotane is first prescribed it is usually given at high levels until it begins to take effect. Side effects may be seen during the initial dosing. Once it takes effect the dosing is usually reduced.
If a dose of Mitotane is missed, give it as soon as you remember. If you remember when it is almost time for the next dose, skip the one you missed and get back on your regular schedule. Do NOT double the dosing.
Common side effects from Mitotane include:
Some side effects could result in liver damage especially dogs with pre-existing liver conditions; signs of this include:
Contact your veterinarian if you think your dog has any medical problems or side effects while taking Mitotane. Please be aware that other side effects may occur.
Do not administer to pets that are allergic to mitotane. If your pet has any allergic reactions to the medication please contact your veterinarian immediately.
Do not use in pregnant, or lactating dogs. Use caution when giving to pets that have liver or kidney disease.
Human Precautions: Pregnant women or women trying to get pregnant should not handle mitotane. Wear gloves when handling this medication and wash hands after handling. It can be toxic.
Store in a tight container in a dark area at room temperature, keep away from heat and direct sunlight. Additionally, as with any medication, keep out of children’s reach.
Consult your veterinarian when giving other medications or supplements with mitotane as interactions may occur. Please inform your vet if your dog is currently taking Spironolactone, prednisone, prednisolone, bartbiturates, warfarin and Phenobarbital, as interactions tend to occur when given with Mitotane.
Overdose of mitotane may cause:
If you suspect or know you dog has had an overdose, please contact your veterinarian or emergency vet clinic immediately.