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Chlorambucil

  • Drug Name: Chlorambucil
  • Common Name: Leukeran®
  • Drug Type: Immunosuppressant
  • Used For: Cancer, immune-mediated diseases
  • Species: Dogs, Cats
  • Administered: Tablets
  • How Dispensed: Prescription only
  • Available Forms: Leukeran® 2mg tablets
  • FDA Approved: No

General Description

 

Chlorambucil is an immune system suppressing drug given to pets for immune-mediated disorders such as cancer including leukemia and lymphoma.

 

Chlorambucil is often given in conjunction with other drugs, It is best to give Chlorambucil on an empty stomach. It is considered a very safe drug.

 

How It Works

 

Chlorambucil works by forming a strong bond with nucleic acid, making it impossible for DNA to properly divide and replicate. This makes it impossible for cancer cells and other cells to replicate. It also suppressed antibody production with this method.

 

Storage Information

 

Store in a tightly sealed container in a refrigerator. Additionally, as with any medication, keep out of children’s reach.

 

Missed Dose?

 

If you miss a dose, give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give your pet two doses at once.

 

Side Effects and Drug Reactions

 

Chlorambucil may result in these side effects:

 

  • Damage to the gastro-intestinal tract
  • Low white blood cell count
  • Low platelet count
  • Bone marrow suppression
  • Blood cell deficiency
  • Damage to the kidneys
  • Damage to the liver
  • Kidney disease
  • Lung disease
  • Irreversible infertility in males
  • Hair loss in some dog breeds

 

Chlorambucil may react with these drugs:

 

  • Antineoplastic
  • Bone marrow suppressant
  • Corticosteroid
  • Immunosuppressive drug
  • Protein bound drug
  • Amphotericin B

 

USE CAUTION WHEN ADMINISTERING THIS DRUG TO PETS WITH BONE MARROW SUPPRESSION OR TO YOUNG OR UNDEVELOPED PETS

 

USE CAUTION WHEN ADMINISTERING THIS DRUG TO PREGNANT OR LACTATING DOGS - Chlorambucil may cause birth defects


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