Cancer of the kidney is extremely rare in dogs. If seen, it typically takes the form of secondary invasion of metastatic cancer originating in a distant tissue. In dogs with leukemia disorders, the kidneys can be infiltrated with neoplastic leukemic cells which can severely compromise renal function. There is also a form of leukemia in dogs that targets the kidneys and crowds out normal kidney cells.
External Toxins (Poisonings)
One of the most devastating external toxins that causes kidney failure in dogs is antifreeze that contains ethylene glycol. It doesn't take much of this sweet tasting liquid to prompt crystals to form in the delicate tubules of the kidney's filtration systems. Other renal toxins include Vitamin D, thallium, turpentine, heavy metals such as lead and mercury, even parts of a Easter Lily. There is also evidence that raisins/grapes can be nephrotoxic to dogs.
Endotoxins are chemicals produced within the animal that are toxic. The most common type is that group of poisons formed by certain types of bacteria. Clostridia organisms are famous for causing tetanus. Many bacteria produce toxins from their normal metabolic waste products. In others, when they die off they leave behind toxins that can have damaging effects on delicate body tissues such as kidney structures and heart valve tissues.
Endotoxins can have systemic effects as well and play a role in triggering shock in an animal where blood pressure declines, heart output diminishes and body tissues become starved for oxygen and nutrients. The resulting shock can leave irreversible damage in any organ of the body, including the kidneys.
Some types of medications can be nephrotoxic such as acetaminophen (analgesic), amphotericin B (antifungal), kanamycin (antibiotic), neomycin (antibiotic), polymyxin B (antibiotic), cisplatin (a cancer drug), penicillamine (chelating agent/immune modulator), Cyclosporine (immunosuppressive), amikacin (antibiotic), and radiographic contrast agents.
Systemic Lupus Erythematosis (SLE), also known as the great imitator, can be difficult to diagnose since it can manifest as a disease of the skin/mucous membranes/nails, kidney and/or joints. As a consequence of the animal's adverse and abnormal immune response to its own body tissues and proteins, many organ sites can be affected, including the kidneys.
As the kidneys filter the circulating blood the abnormal immune molecules are trapped in the glomeruli and blood vessels, causing the kidney to leak protein. A condition called Glomerulonephritis is the result and all sorts of abnormal kidney function can occur due to the damaged glomeruli.
Although not proven to be a result of an autoimmune disorder, the deposition of protein called Amyloid can actually occur in any tissue of the body. The kidneys are most commonly affected and since the protein deposition destroys normal function, renal amyloidosis can be particularly serious due to the fact that kidney tissue does not repair itself.
The bone inside the penis of canine animals
The amount of pressure required to cause osmosis to stop
The term for the hip and related area
A medical condition in which the kidney becomes inflamed
The inside part or region of something
The dilation of the pelvis due to obstruction of urine
An increase in the number of bad white blood cells
A medical condition involving excessive thirst
The failure of the kidneys to perform their proper functions
A condition in which waste builds up in the bloodstream
The tubular shaft found between the kidneys and the bladder
A tube found between the bladder and the outside of the body; used to assist in urination.
A type of nervous system disease in which the patient is unable to regain control over certain muscles, usually those in the neck and jaw
Something that is related to the whole body and not just one particular part or organ
Glucose in the urine of an animal
Found underneath the dermis
A medical condition in which the glomeruli become inflamed
The amount of pressure applied by the blood on the arteries.
Any female animal that has given birth.
A medical condition in which the body has lost fluid or water in excessive amounts
The smaller veins or arteries that extend out from larger arteries.
When a certain organ or vital tissue fails to properly or fully develop.
Term used to imply that a situation or condition is more severe than usual; also used to refer to a disease having run a short course or come on suddenly.
Any medication that is designed to aid in relieving pain without being a sedative.
Moving downward or toward the end
A procedure used to get waste out of the blood when the kidneys are unable to function
To carry something away
Inducing death on an animal or putting them to sleep
A localized infection, usually a lesion filled with pus. Can be large or small in size.
A condition in which growth and development are not up to normal standards
A passage in the body with walls
To make something wider
The furthest distance from the middle or the top of a body
A group or clumps of capillaries