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Lymphocytic-Plasmacytic Gastroenteritis in Dogs

Lymphocytic-plasmacytic gastroenteritis is an inflammatory bowel disease (IBD) in which lymphocytes and plasma cells enter the lining of the stomach and intestines. It is thought to be caused by an abnormal immune response to environmental stimuli due to loss of normal immune regulation, in which bacteria in the intestine may be a trigger. Continued antigen exposure, along with unregulated inflammation, results in disease, although the exact mechanisms and underlying factors remain unknown.

Lymphocyic-plasmacytic gastroenteritis is the most common form of IBD affecting dogs (and cats). Basenjis, Lundenhunds, and Soft-coated Wheaton Terriers have particular familial forms of IBD.

Symptoms and Types

Signs vary dramatically from patient to patient depending on disease severity and the organ affected. Symptoms to look for include:

• Intermittent, chronic vomiting
• Chronic, small bowel diarrhea
• Loss of appetite (anorexia)
• Long-term weight loss (cachexia)
• Black stoll
• Blood in the stool (red)
• Coughing up/vomiting up blood

Causes

• Genetic predisposition
• Bacterial and parasites infections
• Overgrowth of normal bacteria found in the intestines and stomach is suspected
• Possibly altered intestinal bacterial populations and immune alterations
• May be related to meat proteins, food additives, artificial coloring, preservatives, milk proteins and gluten (wheat)

Diagnosis

Your veterinarian will do a complete physical exam and take a thorough history from you. A chemical blood profile, urinalysis, and an electrolyte panel will be ordered. Depending on their results, he or she may run intestinal tests or take blood to check the function of your dog’s thyroid and pancreas.

An endoscopy may be performed, which is very useful for the veterinarian to get a clearer look at the condition of the stomach and intestines, and to take samples for testing. In addition, a fecal sample will be taken for microscopic analysis to check for parasites.