Hi stranger! Signing up for MypetMD is easy, free and puts the most relevant content at your fingertips.

Get Instant Access To

  • 24/7 alerts for pet-related recalls

  • Your own library of articles, blogs, and favorite pet names

  • Tools designed to keep your pets happy and healthy



or Connect with Facebook

By joining petMD, you agree to the Privacy Policy.

PetMD Seal

Abnormal Protein Production in Dogs

ADVERTISEMENT

Paraproteinemia in Dogs

 

Plasma cells are white blood cells, which produce large quantities of antibodies, essential to the body's immune response to invasions of bacteria and viruses. Antibodies are also called immunoglobulins, small protein molecules found in the blood or other body fluids and used by the immune system to fight against foreign particles, including bacteria and viruses. 

 

In paraproteinemia, abnormal proteins called paraprotein (proteins in the blood or urine), or M component, are produced by a single clone (group) of plasma cells. Such production of abnormal proteins is commonly seen in plasma cell tumors and may also be seen in some other types of tumors. This condition is usually seen in middle-aged to older dogs.

 

Symptoms and Types

 

  • Generalized weakness
  • Lethargy
  • Lameness
  • Nose bleed
  • Blindness
  • Increased thirst and urination
  • Seizures
  • Memory loss

 

Causes

 

  • Cancers
  • Genetic predisposition
  • Viral Infections
  • Exposure to carcinogens (e.g., paints or solvents)

 

Diagnosis

 

You will need to give a thorough history of your dog's health, onset of symptoms, and possible incidents that might have led to this condition, such as infections, or contact with carcinogenic substances. Your veterinarian will perform a thorough physical examination, including routine laboratory testing. A complete blood profile will be conducted, including a chemical blood profile, a complete blood count, and a urinalysis. Blood testing may reveal anemia, abnormally low levels of leukocytes or white blood cells (leukopenia), or abnormally low levels of platelets (thrombocytopenia).

 

A biochemistry profile may show abnormally high levels of proteins in the blood, low levels of albumin (a type of protein), abnormally high levels of calcium (hypercalcemia), and high levels of urea and creatinine in the blood. The urinalysis may show the presence of protein in the urine (proteinuria). More specific testing will also be conducted to diagnose various diseases.

 

Thoracic and abdominal X-rays will be taken to identify where lymphoma is present. A sample of bone marrow may be taken, which will reveal more details associated with this disease. Similarly, samples from affected lymph nodes will also be taken to identify the type of cancer cells or infectious agents that are attacking the body.

 

 

Related Articles

Skin Cancer (Mucocutaneous Plasmacytoma) in ...
A mucocutaneous plasmacytoma is a rapidly developing skin tumor of plasma cells origin....
READ MORE
Leukemia (Acute) in Dogs
Acute lymphoblastic leukemia is a disease in which cancerous lymphoblasts (cells...
READ MORE
Anal Gland Cancer in Dogs
While anal gland/sac cancer (adenocarcinoma) is not common, it is an invasive disease...
READ MORE
  • Lifetime Credits:
  • Today's Credits:
Hurry Before All Seats are Taken!
Enroll
Be an A++ Pet Parent! Take fun & free courses to earn badges & certifications. Choose a course»

Latest In Dog Nutrition

How Your Overweight Pet Could Benefit from ...
Pet obesity has reached epidemic proportions. Fortunately, there are some things...
READ MORE
Does My Senior Dog Need Special Dog Food?
Whether or not your senior dog needs special dog food depends, to a large extent,...
READ MORE
How Obesity May Shorten Your Pet's Lifespan
Obesity is a nationwide epidemic for our pets. Unfortunately, being obese can shorten...
READ MORE
Around the Web
MORE FROM PETMD.COM