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Bartonellosis is an infectious bacterial disease, caused by the gram-negative bacteria Bartonella henselae. It is also commonly known as cat scratch disease (CSD), or "cat scratch fever."
This is a zoonotic disease, meaning that it can be transmitted between animals and humans. In cats, the disease is generally transmitted through contact with flea feces. The bacterium is excreted through the flea and into its feces, which it leaves on the cat's skin. The cat, through grooming itself, ingests the bacteria, thereby becoming infected with the Bartonella strain. Humans do not acquire this infection from flea reservoirs. It is important to note that this bacterial infection can also be transmitted to humans and cats by ticks.
Although cats generally do not suffer from the infection, beyond possible fever, swollen glands, and some muscle aches, the infection can be passed to a human host when the infected cat scratches or bites a human. Saliva can also be a conduit for transmission, such as when an infected cat licks a skin abrasion or open wound on a human.
While infection of the Bartonella bacterium is usually mild in humans, it has been estimated that in the U.S. alone over 25,000 cases of cat scratch disease require brief hospitalization each year. Many of the infected are children, as children are most likely to play with kittens – which in turn are the most likely to scratch and bite as part of play.
Symptoms may become apparent within 7-14 days after the injury, but may take as long as eight weeks to present. Typical symptoms are swelling of the lymph nodes nearest to the bitten or scratched site, fever, headache, and a general malaise. Generally, the symptoms merit no more than a brief rest period until they resolve on their own, usually without medical treatment. Some patients require a course of antibiotics.
Fortunately, this disease is not fatal for humans, but it still poses great risks to immunocompromised patients, such as those with the AIDS virus, or those undergoing chemical treatment. While many cat owners do not need to concern themselves with whether their cats are carriers of this bacterium, those who must guard their health are advised to have their cats tested and treated, as well as to be especially vigilant against fleas.
The majority of affected human patients are less than 21 years of age. In humans the following symptoms may be seen:
Symptoms in cats include:
For affected humans, there is usually a history of being scratched or bitten, even lightly, by a cat. In many patients there is a characteristic small, reddish, rounded bump at the site of the scratch or bite. More specific testing may be required to isolate and identify the causative bacterium. As this disease does not cause any symptoms in cats, in most instances no diagnostic workup is required. In severe cases, your veterinarian will take blood samples from your cat for further testing. Complete blood profiles, biochemistry panels, and urinalysis often show no abnormalities.
Further testing will involve more specific tests for confirmation of bartonella infection. Growing, or culturing, the causative organism from a blood sample remains the most reliable method for diagnosis. Polymerase chain reaction (PCR) is a more advanced test for detecting bacterial DNA, which may be done by taking a sample of tissue from the lesion. Even so, these tests do not always confirm bartonellosis as a cause for the disease, since the bacteria is not constantly circulating through the blood stream. Multiple tests may need to be conducted in order to ascertain the presence of Bartonella henselae.
Finally, an enzyme immunoassay (EIA) may be used to test your cat for an immune response to the Bartonella henselae bacterium, but the presence of antibodies does not necessarily mean that the cat is presently infected, only that is has carried the infection at some point in its life.
A lesion of the skin less than half a centimeter in diameter
The prediction of a disease’s outcome in advance
An in-depth examination of the properties of urine; used to determine the presence or absence of illness
General discomfort of the body
A product made of fluid, cell waste, and cells
Small structures that filter out the lymph and store lymphocytes
A substance that causes chemical change to another
A change in the way that tissue is constructed; a sore
The condition of being drowsy, listless, or weak
The singular form of the word bacteria; a tiny, microscopic organism only made up of one cell.