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Nutrition Nuggets
Your dog's nutrition is important for a healthy & happy life. petMD experts help you to know what to feed your dog, how much food to feed, and the differences in dog foods, so your dog gets optimum nutrition.
Nutrition Nuggets is the newest offshoot of petMD's Dog Nutrition Center. Each week Dr. Coates will use her expertise and wisdom to blog about the intricacies of dog nutrition.

Treating and Preventing Bladder Stones in Dalmatians

July 19, 2013 / (3) comments

Dalmatians … a gorgeous breed, no doubt, but one that has resulted in dogs with more than their fair share of health problems.

Dalmatians carry a genetic mutation that alters the way in which they metabolize and excrete substances called purines, which are found in many foods, especially meats. Normally, excess purine is broken down via the following pathway:

  1. Purines are converted to hypoxanthine.
  2. Hypoxanthine is converted to xanthine.
  3. Xanthine is converted to uric acid.
  4. Uric acid is converted to allantoin, which is excreted in the urine.

Virtually every Dalmatian lacks the ability to perform step four, therefore their urine contains unusually high levels of uric acid. All of them do not go on to form medically significant stones, however. I’ve seen estimates that say approximately one-third of male Dalmatians develop urate stones that require medical attention. The percentage is smaller in females, perhaps because they have wider urethras allowing them to pass small stones unaided.

The good news is that urate stones in Dalmatians can often be treated and prevented with dietary modifications and medications. In other cases, surgery to remove the stones is necessary, but as long as the dog is able to urinate freely and can be kept comfortable while the stones are present (it usually takes 2-3 months for the stones to dissolve), medical treatment is certainly worth a try. Protocols involve:

  • feeding a diet that is low in purines. Several manufacturers make appropriate foods.
  • giving a medication (allopurinol) that inhibits the enzyme (xanthine oxidase) that is needed to form uric acid. We have to be careful not to use too much allopurinol and not to use it with a high purine diet. Under these conditions, dogs can form xanthine stones (see step 3 above).
  • promoting the formation of neutral to alkaline urine (urates tend to form more readily in acidic urine) by adding sodium bicarbonate or potassium citrate to the diet.
  • treating urinary tract infections with antibiotics.
  • promoting the formation of dilute urine by encouraging water intake, feeding canned foods, and possibly giving fluids under the skin.
  • if stones are small enough, they may be removed by filling the bladder with a sterile liquid and then squeezing firmly through the body wall to push them out (this works best in females).

Once a Dalmatian has had urate stones that have been cleared either through medical dissolution or surgery, the focus turns to prevention. Some dogs can be managed on a low purine diet, increased water intake, and a urinary alkalinizer. Canned, commercially prepared foods designed for dogs with or at risk for urate stones typically cover all three of these factors; so could a homemade diet designed by a veterinary nutritionist. But sometimes diet alone isn’t enough.

Close monitoring through frequent urinalyses and blood urea nitrogen measurements can determine whether treatment failure is caused by the dog eating high purine foods, the need for more fluids or urinary alkalinizers, or if long term use of allopurinol might be called for, despite the associated risk of xanthine stones.

Treating and preventing bladder stone formation in Dalmatians is nothing if not a balancing act.

Dr. Jennifer Coates

Image: Thinkstock

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Comments  3

Leave Comment
  • Urate Stones
    07/19/2013 05:25pm

    With the many things that should be considered when picking a dog to join the family, if someone is partial to Dalmations, it seems that being willing to "be on the lookout" as well as willing to deal with this problem would be a consideration. It might also be a consideration to lean toward getting a female.

  • 07/19/2013 10:55pm

    Spread the word about the success of the Dalmatian-Pointer backcross project. Supported by genetic research, this project provides hope for a future of non-stone-forming Dalmatians!

  • Puppy buyers
    07/20/2013 11:50am

    I would suggest for anybody getting a Dalmatian to look for breeders who are involved with the Dalmatian-Pointer backcross initiative and see if they can find a puppy that does not have this mutation. If more buyers were seeking out breeders who are involved with this, the more likely it is that more effort will be put into decreasing or eliminating this disease.




Photo of Jennifer

... graduated with honors from the Virginia-Maryland Regional College of Veterinary Medicine in 1999. In the years since, she has practiced veterinary medicine in Virginia, Wyoming, and Colorado. She is the author of several books about veterinary medicine and animal care, including the Dictionary of Veterinary Terms, Vet-Speak Deciphered for the Non-Veterinarian .

Jennifer also writes short stories that focus on the strength and importance of the human-animal bond and freelance articles relating to a variety of animal care and veterinary topics. Dr. Coates lives in Fort Collins, Colorado with her husband, daughter, and pets.