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Dr. Coates is a veterinarian based in the other “Sunshine State” – that's Colorado to the rest of you – where she lives and plays with a varied range of animals. She shares her professional and personal experiences, Monday through Friday, here on petMD's blog, the Fully Vetted. Log in for your daily dose of her insight and wisdom.

 

Hyperthyroidism in cats: reversible symptoms and excellent outcomes'¦with the help of a little cash

March 29, 2007 / (15) comments


Your older kitty seems to get skinnier every day—but his appetite? It’s better than ever! Somehow, the early signs of weight loss in the face of a good appetite seem to go largely unreported. Mostly because cat people are happy to see their kitty eat so well, but also because they know all those extra pounds were making him sluggish and slow.

But by the time owners notice their kitty’s gone beyond “healthy” skinny, she looks like death warmed over.

Cancers, diabetes and other disorders manifest this way commonly in cats. But none in such splendid fashion as when they’re suffering from feline hyperthyroidism. The hallmarks of the disease are rapid weight loss, an increased appetite and often an increased activity level.

Hyperthyroidism is the most common hormone–related illness in cats, usually affecting just our geriatrics. Because the most common age of diagnosis is around thirteen (and because by the time they’re diagnosed they’re looking like sickly skeletons) most owners assume the end is near and often choose not to treat the disorder.

But hyperthyroidism, a disease where the thyroid gland becomes enlarged and overactive, is eminently treatable. For vets who know how easy a cure can be, thyroid disease can be incredibly frustrating when owners choose “to let my pet go instead of putting her through the hardship of treatment.”

Sure, there are times when other factors compete with their candidacy for treatment, but usually, it’s the price that makes owners balk.

“$1,200 for a dying, withered-out cat? Who does this vet think she is? Sure, if I had her salary…”

The thousand-plus bucks in this case is for a treatment called radioactive iodide therapy (I131). Giving an injection of radioactive stuff, should kitty be basically sound (for a geriatric cat), is almost always 100% curative. Although they have to stay in a special hospital facility for a few days to get rid of their radioactive waste (hence the cost), they tend to respond almost immediately to the treatment.

Problem is, this [often prohibitively expensive] approach is the only one that seems truly effective. The most common approach, an oral chemotherapeutic called methimazole (Tapazole) is expensive (rivaling the iodide treatment—penny for penny—within two years), difficult (requires daily pilling), is fraught with numerous side-effects (vomiting and diarrhea), requires regular bloodwork to ensure the appropriate level of medication is maintained and sometimes isn’t even effective at controlling the symptoms.

The next most common alternative approach? Surgery. Again, it’s usually an incomplete approach that requires lots of follow-ups as well as medication, in many cases. It, too, carries all the side effects of any anesthetic procedure carried out on a sick geriatric (not the best odds, IMHO). And it’s only slightly less expensive, up-front, than the iodide approach. After a year, what’s the difference?

With all those strikes, you’d think the iodide treatment would win, hands down. But it doesn’t. People still freak when you say “one-thousand-two-hundred.”

I guess I can understand why a cat that looks like he’s dying (because he is) makes people reluctant to shell out big cash on his behalf. And I guess the modest improvements they see with the “next best” therapies seem like an appropriately frugal approach. But they’re not.

Why is it that when older cats get hit by a car or attacked by a dog that people tend to fish out their wallets but when we offer a complete cure they run screaming away? I don’t quite get it. If we had no option but the best then perhaps then we’d see better treatment.

I know I’m not the only vet with this problem. I know others who complain of the very same thing. That’s why researchers are moving quickly to devise tests to detect the disease earlier. This way we can screen a cat for the disease before she looks like a ghost of herself.

Interestingly, this research has also led us to conclude that diet and other environmental factors may be at least partly to blame for hyperthyroidism. Wet diets high in liver and fish may well contribute (but we’re not completely sure yet). Some plastic collars may also put cats at risk (but, again, we’re not sure). Stay tuned for more…

For my part, I’m going to start offering iodide therapy as the one and only treatment, describing the other approaches as potentially doable for mere management of symptoms (in serious money cases). Because when it comes right down to it, properly treated cats live much longer, healthier, more comfortable lives than anyone ever expects from the dying cat I see on that first visit.

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COMMENTS (15)
1
by on 01/21/2010 12:49am

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2
by on 10/17/2008 12:06pm

Consider the topical approach. You can use this gel on the ear tips for successful methimazole use. I use RoadRunner pharmacy. They ship all over the US. Ask your vet about this method. I don't recommend that you not treat so best of luck with this method.

3
by on 10/17/2008 11:57am

We have a 17 year old cat that has hyperthyroidism. She weighed 9 pounds as a slightly overweight middle age cat - she now weighs 3 1/4 pounds. We live in a very rural area with only one vet clinic. The cost of the RI treatment is way beyond our means and our cat is much too feeble and nervous to subject to repeated vet visits for blood tests, etc. Even if we could get the methamazole she is impossible to pill and manages to avoid anything hidden in her food.
We are at a loss as to what to do. She seems content (other than being hungry all the time). She eats the dry food that is out for our other cats but in addition we feed her wet food several times a day - which she much prefers. When she wants to eat she goes in the bathroom - we have to feed her there to keep the others out of her food - climbs up on the counter and knocks things off til we come with food. If her stool gets runny, we mash up some rice in her wet food and it seems to firm things up. When she isn't eating she sleeps and loves to stretch out in the sun or climb up on us for a tummy rub. She purrs constantly.
My question is what will the outcome be if we don't do anything? Are we being cruel? We truly love this little cat and want to do the best we can for her but vet visits seem to be the worst of two evils.

4
by on 05/11/2007 12:39am

My cat is about 11 (we found her so not sure) and she has hyperthyroidism for about 1 year now and now last week was just diagnosed with diabetes. I'm nervous because of all the medication she is taking for both. She is on the pill for hyperT and getting two shots of insulin a day for diabetes. The vet changed her food to a low carb/high protein diet but I just read that food high in liver or fish could also be a cause of hyperT? I don't know if her food has liver in it or not but I have to crush her pills in wet food to make her take it and it has fish and liver. I am just nervous about everything and want her to live. I hope I'm doing the right thing. Any advice?

Thanks.

5
by on 04/09/2007 04:14pm

I can't help but feel that you are painting too simplistic a scenario. My cat was 18 when diagnosed with hyperT. We opted for the methamazole for her. This was not an easy decision, but for this particular cat, it was the right decision. Why? She had several other ailments, most significantly CRF, which complicated both her diagnosis and her prognosis.

I think most pet owners want to do what they feel is best for the cat, or the best they can given the resources they have, but there are often competing needs and complicating conditions. For you to decide, unilaterally, -- to dictate really -- what you feel is best for a member of someone else's family is, imho, simply not ethical.

I wouldn't trust a vet who would withold information about my pet's and my family's options any more than I would trust a physician who would do this.

6
by on 03/31/2007 10:07am

Andren: Wow! A full 16 days? For us it's really just a couple of days (exactly two). And it's right across the street. It's done athat way all over the state of Florida in every major specialty hospital.

If anyone wants more info on the state of the art in feline hyperthyroidism treatment with I131, go see Dr. Erik Mears' website for his icat service at http://i-cat.info/

7
by on 03/31/2007 01:15am

If it was only a few days in the hospital I would have done it for my hypert cat already, instead of the meds. However there is only one facility in my region that offers this and they require 16 days isolation/quarantine in the hospital for all pets getting the RI treatment. It's very frustrating.

8
by on 03/30/2007 11:31pm

Radiation therapy *is* that curative in humans. I happen to be hyperthyroid myself, and right now, I'm on twice-daily Tapezole--but I see an endocrinologist every three months for an exam and bloodwork, and I'm aware that, if the Tapezole either doesn't work any more or causes nasty side effects, radiation therapy will be the next step.

9
by on 03/30/2007 10:31pm

Hi Patty-
Can you provide a link to a good website detailing pros/cons of different treatments? My parents have a 13-yr-old cat who has been on twice-daily thyroid medication for about 2 years now. I've always wondered if radiotherapy would be an option, but as far as I know their vet hasn't suggested it. Thanks!

10
by on 03/30/2007 09:17am

Betty: Yes, that could well be your kitty's case. As recently as four years ago this therapy was not so nearly widely used. The evolution's been quick. In 2007, though, we'd probably have irradiated your cat immediately. But it's tough if her kidneys are truly starting to shut down. If you wonder, just ask. if you still wonder, talk to an internist--that's what they're there for. Just six months ago I might have considered it an aggressive approach and now I think of it as standard. How many other vets are still where I was six months ago? Tons. (Probably as many as were ahead of me by six months.) Medicine in cats is evolving very quickly now.

11
by on 03/29/2007 11:57pm

I do have a hyper-t kitty (17 now - diagnosed 4yrs ago) has been on transdermal tapazole. I have asked about I131 and been told that since his bloodwork recently shows him possibly heading towards crf that it would be better to continue the tapazole because playing with the dosage can help with the crf ---- is this true or not?

12
by on 03/29/2007 10:27pm

Maybe it's that scary r word.

Maybe there's room for some better client literature on this. It's hard for people to "get" what containment is all about, especially just after you've told them it's dandy for their pet to take this stuff in. "What do you mean my cat is fine but I can't take him home?"

Plus, I don't think people really get the whole "iodine and thyroid, sittin' in a tree" thing... see Georg, above. Without some real 'splaining, most people won't really believe in their heart of hearts that for this very special cancer, the therapy is so astoundingly well-tailored by nature that it really is better than just about any clever chemotherapy one could invent.

But isn't that a wonderful thing? Americans wouldn't know goiter if they tripped over it. Yay for effective public health measures!

13
by on 03/29/2007 05:51pm

I know that I would gladly shell out the money to treat any of my cats if they had that. From the many, many people I know that have done this, not one of them regrets doing it. And you are right, the cost for the I131 compared to the pilling is equal--and I'd bet in a lot of cases it would be more frugal.

That would be wonderful if more research was done as to what causes hyperT in the first place--especially if the research is aimed at cats. Since 90% of veterinary research is aimed at dogs, any research for kitties would be so worthy (especially since cats' systems and bodies are not just little dogs!) So far, I haven't had a hyperT cat, but I do have one with acromegaly whose thyroid is low (could be euthroid sick syndrome, could be ?), but I know that if I ever do, I'll figure out a way to get the treatment. The price of the radioactive iodine is a bargain compared to the $10,000 it would cost to radiate my acrocat....and the I131 at least has an awesome cure rate (for acromegaly the radiation has a 50% chance at best to work and many times needs to be repeated).

I like your plan of presenting the I131 as THE treatment. I hope it leads to many kitties being successfully treated.


Carolynn

14
by on 03/29/2007 04:33pm

I suppose I should add for clarity, even at 10 pounds, she is a Very Fat Cat. If she was properly proportioned, she should weigh about 6 pounds. I can remember when she weighed *4* as an adult.

15
by on 03/29/2007 04:31pm

If it's that curative in cats, why can't it be that curative in humans? I confess, I'd never heard of that treatment. I assumed it would be a daily pill, just like for humans if the vet told me my kitty had hyperthyroidism. And depending on the cat, that might be an easy route to take. Sassy fat cat is soooo easygoing we could do it no problem.

In fact, that's what I first thought was wrong with Sassy when she went from 12 to 10 in 2 weeks. I thought she was rapidly getting skinny, so took her in for an official weighing, and that made me arrange an appointment for blood work. Our vet will kindly let us weigh any pet when we call ahead at no charge. I take Sassy in often. That blood work led to her diagnosis for diabetes. She gets shots twice a day and is very good about it- she will even purr because of the attention. Her fur was more dandruff than usual too. Now I can tell she needs an adjustment in her insulin if her coat goes "off".

Other cats though- like Tom-- oh he would not be able to pill well unless we could sneak it in food. And I'm not sure how well he'd cope with cage. Probably not well. I pity anyone opening the door even if it's to pet him.

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About fully vetted

Patty Khuly, VMD, MBA

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Dr. Khuly is a former petMD blogger and small animal veterinarian in Miami, Florida, where she practices medicine at Sunset Animal Clinic and serves on the board of the South Florida Veterinary Medical Association. She is a graduate of Wellesley College, the University of Pennsylvania School of Veterinary Medicine, and The Wharton School of Business.

As a significant sideline, she writes...a lot. She authors pet health columns for USA Today, The Miami Herald and Vetstreet. She also writes a popular monthly column for Veterinary Practice News and serves as regular contributor to Veterinary Economics, The Bark, and the Veterinary News Network.

Dr. Khuly lives in South Miami with her brood of hens, goats, dogs, cats...and humans.

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