Q. My dogs alkp was 901 and the vet put him on Denamarin. He had a bile acid test done 2wks later, which was neg. Does he need to stay on rx?
DR. MASSIMO ORIOLES, DVM, MRCVS
A. Usually treatment with Denamarin is recommended for long period of time (30 days or more). The length of the treatment would depend though on the underlying disease that is affecting him. That ideally needs to be recognized. The fact that the bile acids concentration is normal means that the liver's function seems normal (other results would be needed for a full assessment).
Many liver and systemic (endocrine for example) diseases can lead to elevation of ALKP. Hepatitis, cholangiohepatitis, liver tumors, pancreatitis, administration of certain drugs (as steroids), Cushing's diseases, Diabetes mellitus are all different diseases than can cause that elevation. Many others are possible.
I would recommend to discuss with your veterinarian the different options int rems of investigations and treatment.