Q. 4yrs old female, lyme+, collie. Hot spots with severe itching. Vet gave antibiotic and prednisone. Seizures in pm. Why?
DAVID ELBEZE, DVM, MRCVS
A. there are 2 possibilities - the first - seizure can be one of the rare symptoms of lyme disease. The second - it could be a side effect of the Doxycicline if your dog is positive to the gene MDR-1 (Doxy is pumped out by the brain, MDR-1 positive dogs, which are usually collies, have problem metabolizing these drugs and side effect can happen, although no such side effect have been documented with Doxy).
I would advise testing your dog for the MDR-1 gene so you can know in the future not to give him certain medications such as Ivermectin for example.