Q. My dog has these big blister type thing on both sides of her bottom one on each side what could it be
DESTINI R. HOLLOWAY, DVM
A. This sounds very likely to be enlarged or impacted anal glands that could have ruptured. If they are oozing a very fishy smelling thick material then most likely this is the cause. Treatment for this includes flushing out the area really well with chlorhexidine solution (available at Walmart) and an oral antibiotic (i.e. Simplicef) and anti-inflammatory (Carprofen) prescribed by your veterinarian.
If the blisters don't match this description then they may actually just be blisters from trauma to the skin and can be managed with the chlorhexidine solution cleansing daily with a topical antibiotic cream such as Silver Sulfadiazene, which is great for burns and blisters!
- Dr. H