Q. My cat has recently become very sensitive to me scratching his rear end and I have to be careful about holding him without touching his backside...
DESTINI R. HOLLOWAY, DVM
A. He could have a number of things going on here including arthritis (unsure of his age, didn't post) or an abscess (painful bacterial filled swelling just underneath the skin. If the pain persists for more than a day or two, or if you notice a swelling there, then a vet visit could help you narrow down some possibilities here with a good physical examination of your cats musculature (muscles and bones).