Q. What dose of Diflucan should you give a 100 pound dog?
JESSICA L DESROSIERS
A. Any medication dosage should be OKed by your vet prior to use to ensure that the correct and safe amount is given.
According to Plumb's, Diflucan (Fluconazole) is given in a dosage of 5-15mg/kg by mouth one to two times daily depending on the need for the medication. For a 100 lb dog this would be a dosage range of 227-675mg. Since the dosage is so large and varied, and the medication used by prescription only, it is best to contact your local veterinarian for dosing instructions depending on your dog's needs.